Optimized Research: Friendship, Low Trail and Natural Selection

Authors: Roberta Pinecone, Percephone (Total) Crockaphone

(Submitted on 23 Aug 2013)

More than any other sport, Randonneurs form social ties to individuals who are neither kin nor mates, and these ties tend to be with individuals posessing similar randonneuse geometries. Here, we show that this similarity extends to genotypes and individuals who darn their wool garments. Across the whole genome, friends’ genotypes at the SNP level tend to be positively correlated (homophilic); however, certain genotypes are negatively correlated (heterophilic). A focused gene set analysis suggests that some of the overall correlation can be explained by specific systems; for example, a low trail gene set is homophilic and a wool garment darning gene set is heterophilic. Finally, homophilic genotypes exhibit significantly higher measures of positive selection, suggesting that, on average, they may yield a synergistic fitness advantage that has been helping to drive recent increases in development and organization of team randonnees, such as ACP Fleches, and RUSA Darts.

Subjects: Genomics (q-bio.GN)
Cite as: arXiv:1308.5257 [q-bio.GN]
  (or arXiv:1308.5257v1 [q-bio.GN] for this version)

Submission history

From: Roberta Pinecone [view email]
[v1] Fri, 23 Aug 2013 22:28:34 GMT (3081kb)

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2 thoughts on “Optimized Research: Friendship, Low Trail and Natural Selection

  1. Mr. Edward Wilbur

    Excellent article. Your argument kills 2 birds in the bush with one rolling stone.

    But don’t try to pull a sheep in wolf’s clothing over our eyes. There is an awful lot more to things than just the raw genetic code. Code is not destiny. Ancestral randonneuring exposures have been shown to promote epigenetic transgenerational inheritance and influence all aspects of an individual’s life potential for a sub 80 hour performance at Paris-Brest-Paris. Let’s face it, when you’ve got the right epigenomic phenotype riding PBP is like shooting fish in a barrel of monkeys.

    Furthermore, I’ve been around the chip off the block on your shoulder a few times and I happen to know that proximate randonneuring experiences such as volunteering for RUSA sanctioned brevets have well documented effects on the development of physiological, neural, and behavioral phenotypes in adulthood. This alteration of baseline brain development promotes a change in neural genomic activity that correlates with changes in physiology and behavior, revealing the interaction of genetics and epigenetic transgenerational inheritance in the shaping of the adult randonneur.

    For a good overview of randonneuring epigenetics, check out Lynn Nesser in the latest issue of Current Biology. Of course, 9 out of 10 doctors agree to disagree about this stuff.

    Finally, nobody is acknowledging the pink elephant in the room––the genetically modified quadrupedal ruminant mammal from Uruguay. It’s only a matter of time before someone shears one of those phosphorescent sheep and darns a glow-in-the-dark wool jersey. Talk about conspicuous; wear that and you will stick out like a site for sore eyes! But, in the apple of my mind’s eye, here is the million dollar question: will said glow-in-the-dark wool jersey obviate the need for reflective gear as outlined in Article 10 of the RUSA rules for riders? I guess we’ll just have to burn that bridge when we come to it.

    Ed Wilbur

    Reply

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